Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678460
3.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
4.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324999
5.
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.
Bioorg Med Chem Lett
; 18(7): 2311-5, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18358720
6.
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
J Med Chem
; 50(17): 4162-76, 2007 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17658776
7.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
8.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
9.
Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells.
Clin Cancer Res
; 17(22): 7067-79, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21933891
10.
Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides.
J Org Chem
; 61(11): 3584-3585, 1996 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667199
11.
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
J Med Chem
; 52(21): 6621-36, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19842661
12.
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 16(8): 2293-8, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16446090
13.
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Bioorg Med Chem Lett
; 15(1): 153-8, 2005 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15582430
14.
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 13(22): 4001-5, 2003 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14592494